Docosahexaenoic acid (DHA)

Docosahexaenoic acid (DHA)

What is DHA?

DHA is one of the most important omega-3 polyunsaturated fatty acids (PUFAs).1

It is a key component of all cell membranes and is found in high concentrations in the brain and eyes.2 It accounts for up to 25% of total fatty acids in the brain,3 and up to 70% of total fatty acids in parts of the eye's retina.1 DHA has important roles in brain and eye development and function.1

Due to its chemical structure, DHA is susceptible to oxidative damage. Research has demonstrated that vitamin E, a powerful antioxidant, tends to accumulate within membranes abundant in DHA and plays a pivotal role in safeguarding DHA from damage.4

Benefits of DHA

Essential for brain and eye development in children2

Supports cognitive function5,6

Influences learning ability7

Supports heart health1

DHA is the most important omega-3 PUFA for proper cell membrane function and is essential to the normal development of the brain and eye.2

Supply of DHA is particularly important early in life,1 and levels of DHA have been shown to accumulate in the foetal brain during the last trimester of pregnancy and continue up to the end of the second year of life.8 It is therefore important for pregnant and breastfeeding women to get enough DHA in their diet to support their baby's brain and eye development.1

DHA may also influence cognition and IQ.5,6 Studies suggest that DHA intake supports normal IQ,6 and preserves cognitive functions like spatial learning and memory,9 contributing to optimal brain function.

DHA, along with other long-chain omega-3 fatty acids, has been shown to have a positive effect on heart health and may help reduce the risk of heart disease.1

Recommended dietary intake (RDI) of DHA1

There are no specific RDI values for DHA in Australia. Australian dietary guidelines provide RDIs for total long-chain Omega-3 fatty acids, which includes DHA, eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA). These values are provided below by life stage:10

Age groupTotal long-chain Omega-3 Fatty acids (DHA+EPA+DPA), mg/day
1–3 years40
4–8 years55
9–13 years70
14–18 years125 (boys);
85 (girls)
Adults ≥19 years and over160 (men);
90 (women)
Pregnancy115 
Lactation145 

Sources of DHA

Although it is possible for the body to produce DHA from other fatty acids, only a small amount can be made from this process so DHA is essential in the diet.2

DHA is mainly found in oily fish such as mackerel, herring, sardines, salmon, tuna and other seafood.

Seafood

  • Herring
  • Trout
  • Mackerel
  • Salmon
  • Sardine
  • Tuna
  • Microalgae

DHA Fortified Food

  • Milk
  • Eggs
  • Juice

Oil

  • Fish Oil
  • Algal Oil

Signs and consequences of DHA deficiency

Impaired cognitive development and function7

Impaired vision7,11

Increased risk of heart disease12

DHA is important for normal brain development and function.1 Low DHA levels during pregnancy and early life has been associated with poor neural development, decreased learning ability and ADHD in children.7,13

DHA is found in cell membranes of photoreceptors in the eye. A deficiency in DHA reduces the activity of rhodopsin, a protein located in the eye that is responsible for sending visual signals to the brain, thereby resulting in impaired vision.14

Low levels of DHA have been associated with increased risk of heart disease. Studies have shown that higher intakes of DHA and other omega-3 fatty acids, can help reduce heart disease and death by improving risk factors such as blood pressure, cholesterol and inflammation.1,12

Did you know?

DHA helps with certain learning outcomes, visual acuity and brain development.2,5,6,9

Food for Special Medical Purposes. Use only under medical supervision.

ADHD: attention deficit hyperactivity disorder. DHA: docosahexaenoic acid. DPA: docosapentaenoic acid. EDA: eicosapentaenoic acid. PUFA: polyunsaturated fatty acid. RDI: recommended daily intake.

References: 1. Calder, P. Proc Nutr Soc. 2018;77(1):52–72. 2. Swanson D, et al. Adv Nutr. 2012;3(1):1–7. 3. Guesnet P, et al. Biochimie. 2011;93(1):7–12. 4. Raederstorff D, et al. Br J Nutr. 2015;114(8):1113–1122. 5. Weiser MJ, et al. Nutrients. 2016;8(2):99. 6. Cohen JT, et al. Am J Prev Med. 2005; 29(4):366–74. 7. Lauritzen L, et al. Nutrients. 2016;8(1):6. 8. Yurko-Mauro K, et al. Alzheimers Dement. 2010;6(6):456–64. 9. National Health and Medical Research Council, Australian Government Department of Health Ageing, New Zealand Ministry of Health, Nutrient Reference Values for Australia and New Zealand. Canberra: National Health and Medical Research Council. (2006). 10. DiNicolantonio JJ, O'Keefe JH. Nutrients. 2020;12(8):2333. 11. Shindou H, et al. J Biol Chem. 2017;292(29):12054–12064. 12. Ginter E, Simko V. Bratisl Lek Listy. 2010;111(12):680–685. 13. Innis SM. Brain Res. 2008;1237:35–43. 14. Senapati S, et al. Biochim Biophys Acta Biomembr. 2018;1860(6):1403–1413.

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