資料及參考來源

重要說明：母乳是嬰兒最理想的營養來源，充足營養對準備及維持授乳都很重要。若以嬰兒配方餵哺，母親應考慮社會及經濟因素，了解回復授乳的困難，並留意其對母乳餵哺的影響。開始以奶粉餵哺前，應先向醫護人員查詢。

**指新鮮脫脂液奶經殺菌後到成粉一次完成

***Bode L. Glycobiology. 2012 Sep;22(9):1147-62

^根據加拿大指南的2014食品安全報告

^^與市場上添加 Human Milk Oligosaccharide (HMO) 的配方奶粉作比較，雅培於2016年9月在美國推出添加Human Milk Oligosaccharide (HMO) 配方奶粉

^^^EU approved 2'-Fucosyllactose (2'-FL), Commission Implementing Regulation (EU) 2017/2470

+對比2次成粉配方奶粉

++指劇烈加熱後產生的美拉德反應產物

# 與脫脂乳粉相比，脫脂液奶保留更多蛋白質的營養價值

Milk and dairy products in human nutrition. Food and agriculture organization of the united nations. Rome 2013.

##指HMO+NTs配方

※Hill, D. R., Chow, J. M., & Buck, R. H. (2021).

Nutrients. 13(10):3364

△The Environmental Management System of Abbott Nutrition Supply Chain at Cootehill manufacturing Abbott nutritional products has been assessed by Certification Europe and deemed to comply with the requirements of ISO 14001:2015

‡ The Energy Management System of Abbott Nutrition at Cootehill manufacturing infant nutritional products has been assessed by Certification Europe and deemed to comply with the requirements of ISO 50001:2018

¤ NSAI issued an IQNet recognized certificate that the manufacturer of Abbott Similac at the Cootehill site fulfills the requirements of ISO 9001:2015

◊ Elizabeth J. Reverri, Amy A. Devitt, Janice A. Kajzer,Geraldine E. Baggs and Marlene W. Borschel (2018).Review of the Clinical Experiences of Feeding Infants.Formula Containing the Human Milk Oligosaccharide 2'-Fucosyllactose. Nutrients, 10(10), 1346.

△△ Bertelsen, R. J., Jensen, E. T., & Ringel-Kulka, T.(2016). Use of probiotics and prebiotics in infant feeding. Best practice & research. Clinical gastroenterology, 30(1), 39-48.

▲ Goehring, K. et al. J Nutr. 2016 Dec;146(12):2559-2566.§ Goehring, K. et al. J Nutr. 2016 Dec;146(12):2559-2566.Pickering LK, et al. Pediatrics. 1998 Feb;101(2):242-9.Schaller JP, et al. Pediatr Res 2004; 56:883-890.Buck RH, et al. Pediatr Res 2004 Dec;56(6):891-900.

§§ BB-12® 是 Chr. Hansen 的商標及全球最多科學實證的雙歧桿菌。Jungersen, Mikkel et al. “The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis BB-12®.” Microorganisms vol. 2,2 92-110. 28 Mar. 2014.

◊◊ 原生營養指全脂牛乳，比較雅培心美力升級版5HMO第4階段產品。

◊◊◊ 與前配方雅培心美力（含有一種HMO，2'-FL）作比較，升級配方含有5種HMOs支持免疫力。

▲ 截至2024年9月，與全港主要品牌配方奶粉第4階段產品標籤比較，雅培心美力升級版5HMO的益生元母乳低聚糖組合（2'-FL, 3-FL, 3'-SL, 6'-SL, LNT）含量最高，合共180毫克/100毫升，非源自母乳。雅培心美力升級版5HMO的核苷酸含量最高，合共3毫克/100毫升，非源自母乳。

▲▲100位媽媽曾於2022年7月份參與雅培心美力HMO試用活動

^^^^ Lowen AC, Mubareka S, Steel J, Palese P. Influenza virus transmission is dependent on relative humidity and temperature. PLoS Pathog. 2007 Oct19;3(10):1470-6. doi: 10.1371/journal.ppat.0030151.PMID: 17953482; PMCID: PMC2034399.

‡‡ Hill, D.R.; Chow, J.M.; Buck, R.H. Multifunctional.Benefits of Prevalent HMOs: Implications for Infant.Health. Nutrients 2021, 13, 3364.

‡‡‡ Hill, D.R.; Chow, J.M.; Buck, R.H. Multifunctional.Benefits of Prevalent HMOs: Implications for Infant.Health. Nutrients 2021, 13, 3364. Li, Zeyu et al.

Occurrence, functional properties, and preparation of 3-fucosyllactose, one of the smallest human milk oligosaccharides. Crit Rev Food Sci Nutr. 2022 Apr19:1-15.

‡‡‡‡ Jungersen, Mikkel et al. “The Science behind the Probiotic Strain Bifidobacterium animalis subsp.lactis BB-12®.” Microorganisms vol. 2,2 92-110. 28 Mar.2014.

δ Walsh C, et al. J Funct Foods. 2020;72:104074.Bode L. Glycobiology. 2012;22(9):1147-1162.Hill, D. R., Chow, J. M., & Buck, R. H. (2021). Nutrients.13(10):3364.

φ Lasekan JB et al., Impact of palm olein in infant formulas on stool consistency and frequency: a meta-analysis of randomized clinical trials. Food Nutr Res.2017 Jun;61(1):1330104

Auestad et al., Growth and development in term double-masked, randomized, parallel, prospective,multivariate study. Pediatrics. 2001 Aug;108(2):372-81.

◆◆ 指雅培心美力升級版5HMO的第1至第4階段配方奶粉

◆ Furness JB, Kunze WA, Clerc N. The American journal of physiology. Nov 1999;277(5 Pt 1):G922-928.

δ 有助守護腸道，幫助強化先天免疫力。Bode L.Glycobiology. 2012;22(9):1147-1162. Goehring, K. et al.J Nutr. 2016 Dec;146(12):2559-2566. Similar to Those, Who Are Breastfed, Infants Fed a Formula Containing 2'-Fucosyllactose Have Lower Inflammatory Cytokines in a Randomized Controlled Trial

♣ Pickering LK, et al. Pediatrics. 1998 Feb;101(2):242-9.Yau, Kuo-Inn Tsou et al. Journal of pediatric gastroenterology and nutrition vol. 36,1 (2003): 37-43.

▲ The innate and adaptive immune systems. Last Update: July 30, 2020. https://www.ncbi.nlm.nih.gov/books/NBK279396/

▹ 指配方含 5HMO（180mg/100ml）+ NTS（3.0mg/100ml）

◼ The innate and adaptive immune systems. Last Update: July 30, 2020. https://www.ncbi.nlm.nih.gov/books/NBK279396/

◙ 有助增加百喉疫苗抗體數量（免疫球蛋白A），飲用含核苷酸強化配方（72mg/L）的1-7天大之嬰幼兒與對比組比較。在為期48週的研究，IgA抗體指數顯著較高。Yau KI, et al. J

Pediatr Gastroenterol Nutr. 2003;36(1):37-43.

● 偶發性腹瀉：飲用含BB-12®配方的0-8個月大之嬰幼兒與對比組比較。Chouraqui JP, et al. J Pediatr Gastroenterol Nutr. 2004;38(3):288-292

◐ 飲用含2'-FL HMO 心美力配方的5-119天大之嬰幼兒與飲用不含2'-FL HMO心美力配方的對比組比較。Reverri EJ, et al. Nutrients. 2018;10(10):1346.

◑ NTs指 Nucleotides 核苷酸（3毫克/100毫升）。

▶ 5種母乳低聚糖HMOs組合（2'-FL, 3-FL, 3'-SL, 6'-SL, LNT）合共180毫克/100毫升，非源自母乳。

▣ 飲用含核苷酸強化配方與對比組比較，有助增加乙型流感嗜血桿菌疫苗(Hib)抗體數量。Pickering LK, et al.Pediatrics. 1998;101(2):242-249.

◧ 飲用含核苷酸強化配方與對比組比較，有助增加白喉疫苗抗體數量(IgG)。Pickering LK, et al. Pediatrics.1998;101(2):242-249.

** Hill, D. R., Chow, J. M., & Buck, R. H. (2021).Nutrients. 13(10):3364.Jungersen, Mikkel et al. “The Science behind the Probiotic Strain Bifidobacterium animalis subsp. lactis

BB-12®.” Microorganisms vol. 2,2 92-110. 28 Mar. 2014.

*** 飲用含核苷酸強化配方與對比組比較，有助增加Tc1細胞。

Buck RH, et al. Pediatr Res. 2004;56(6):891-900.

**** Sevelsted A, et al. Pediatrics 2015;135:e92-8.

◣◣ Male D. et al. (2013). Antibodies. In: Immunology.8th ed. Elsevier Inc. 51-70

❖ 飲用含BB-12®配方的幼兒與對比組比較。Chouraqui JP,et al. J Pediatr Gastroenterol Nutr. 2004;38(3):288-292

※※ 指研究觀察到較高的2'-FL攝取量與膽汁酸代謝顯著增加之間的關聯，其與血漿中的免疫調節劑濃度呈正相關。Hill, D. R., & Buck, R. H. (2023). Infants Fed Breastmilk or 2'-FL Supplemented Formula Have Similar Systemic Levels of Microbiota-Derived Secondary Bile Acids. Nutrients,15(10), 2339.

▼ 根據品牌內部數據，截至2024年6月，與全港主要品牌配方奶粉第4階段標籤比較，雅培心美力為全港唯一品牌含3mg/100ml核苷酸；科研實證，飲用含核苷酸強化配方與對比組比較，有助增加乙型流感嗜血桿菌(Hib)抗體數量。Pickering LK, et al. Pediatrics. 1998;101(2):242-249.

▶ 第28天與基線相比。在一項單臂研究中，對45名嬰兒進行了研究，這些嬰兒在使用不同的配方奶粉時被父母認為非常之極其挑剔。Reverri, Elizabeth et al. (2023). P07-068-23 Parent-Reported Improved Gastrointestinal Tolerance and Parental Perspectives in Infants Identified as Fussy and Fed Infant Formula With 5 Human Milk Oligosaccharides. Current Developments in Nutrition. 7. 101058.

■ 飲用含2'-FL HMO心美力配方的5-119天大之嬰幼兒與飲用不含2'-FL HMO心美力配方的對比組比較。

Reverri EJ, et al. Nutrients. 2018;10(10):1346.

*純屬個人分享